ID   UM4-6
AC   CVCL_B840
DR   GEO; GSM3053264
DR   GEO; GSM3053265
DR   NIHhESC; NIHhESC-12-0147
DR   Wikidata; Q54991044
RX   PubMed=28445466;
RX   PubMed=30158855;
RX   PubMed=31374463;
WW   Info; U-M; -; https://record.umich.edu/articles/a3647-new-stem-cell/
WW   Provider; MStem Cell; -; https://www.mstemcell.org/purchase-stem-cell-lines/
CC   From: University of Michigan; Ann Arbor; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-12-0147.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Donor information: Embryo is sibling to those giving rise to UM4-9 (Cellosaurus=CVCL_5H77), UM4-11 (Cellosaurus=CVCL_5H75), UM4-12 (Cellosaurus=CVCL_5H76) and UM4-13 (Cellosaurus=CVCL_WW08).
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
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RX   PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative p53 mutations.";
RL   Nature 545:229-233(2017).
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RX   PubMed=30158855; DOI=10.3389/fnmol.2018.00282; PMCID=PMC6104480;
RA   Haenfler J.M., Skariah G., Rodriguez C.M., Monteiro da Rocha A.,
RA   Parent J.M., Smith G.D., Todd P.K.;
RT   "Targeted reactivation of FMR1 transcription in fragile X syndrome
RT   embryonic stem cells.";
RL   Front. Mol. Neurosci. 11:282.1-282.17(2018).
//
RX   PubMed=31374463; DOI=10.1016/j.scr.2019.101504; PMCID=PMC6736695;
RA   Moore L.R., Keller L., Bushart D.D., Delatorre R.G., Li D.-J.,
RA   McLoughlin H.S., do Carmo Costa M., Shakkottai V.G., Smith G.D.,
RA   Paulson H.L.;
RT   "Antisense oligonucleotide therapy rescues aggresome formation in a
RT   novel spinocerebellar ataxia type 3 human embryonic stem cell line.";
RL   Stem Cell Res. 39:101504-101504(2019).
//