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Cellosaurus SRD-14 (CVCL_B7PA)

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Cell line name SRD-14
Synonyms Sterol Regulatory Defective-14
Accession CVCL_B7PA
Resource Identification Initiative To cite this cell line use: SRD-14 (RRID:CVCL_B7PA)
Comments Selected for resistance to: ChEBI; CHEBI_77317; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol] (SR12813).
Transformant: NCIt; C129643; Cesium-137 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene deletion; UniProtKB; Q8CFA6; Insig1; Zygosity=Heterozygous; Note=The 2nd allele has a loss of function (PubMed=15247248).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D893 (CHO-7)
Children:
CVCL_B7PB (SRD-14/pInsig-1)CVCL_B7PC (SRD-14/pInsig-2)CVCL_B7PD (SRD-15)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=15247248; DOI=10.1074/jbc.M406406200
Navdar Sever, Peter C.W. Lee, Bao-Liang Song, Robert B. Rawson, Russell A. DeBose-Boyd;
Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Biol. Chem. 279:43136-43147(2004)

PubMed=15866869; DOI=10.1074/jbc.M502989200
Peter C.W. Lee, Navdar Sever, Russell A. DeBose-Boyd;
Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
J. Biol. Chem. 280:25242-25249(2005)

Cross-references
Encyclopedic resources Wikidata; Q112930417
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6