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Cellosaurus A375-Luc-RFP (CVCL_B7NR)

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Cell line name A375-Luc-RFP
Synonyms Luciferase/tdTomato Dual-Reporter A375 Cell Line
Accession CVCL_B7NR
Resource Identification Initiative To cite this cell line use: A375-Luc-RFP (RRID:CVCL_B7NR)
Comments Population: Caucasian.
Characteristics: Transduced with a SFFV-Luc-PGKp-tdTomato-T2A-PuroR lentiviral reporter construct.
Genetic integration: Method=Transduction; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages Provider; ALSTEM; LRL02; https://www.alstembio.com/web/product_details.php?id=35
Cross-references
Cell line databases/resources cancercelllines; CVCL_B7NR
Encyclopedic resources Wikidata; Q112927058
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number9