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Cellosaurus PEO4-iPSC-OSKM-03 (CVCL_B7JI)

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Cell line name PEO4-iPSC-OSKM-03
Accession CVCL_B7JI
Resource Identification Initiative To cite this cell line use: PEO4-iPSC-OSKM-03 (RRID:CVCL_B7JI)
Comments Population: Caucasian.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Tyr1655Tyr (c.4965C>T) (5193C>T); ClinVar=VCV001657967; Zygosity=Hemizygous; Note=De novo mutation that cancels the c.4965C>G (5193C>G) mutation in the patient (from parent cell line).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg160Trp (c.478A>T); ClinVar=VCV000412204; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly244Asp (c.731G>A); ClinVar=VCV000372785; Zygosity=Homozygous (from parent cell line).
Disease BRCA2 syndrome (NCIt: C36101)
Ovarian cystadenocarcinoma (NCIt: C5228)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2690 (PEO4)
Sex of cell Female
Age at sampling Age unspecified
Category Induced pluripotent stem cell
Publications

PubMed=34343671; DOI=10.1016/j.biocel.2021.106051
Sadhanandhan Bindhya, Chirukandath Sidhanth, Syama Krishnapriya, Manoj Garg, Trivadi S. Ganesan;
Development and in vitro characterisation of an induced pluripotent stem cell model of ovarian cancer.
Int. J. Biochem. Cell Biol. 138:106051.1-106051.15(2021)

Cross-references
Encyclopedic resources Wikidata; Q114312650
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7