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Cellosaurus AGS-5FU-R (CVCL_B7H2)

[Text version]
Cell line name AGS-5FU-R
Synonyms AGS-R
Accession CVCL_B7H2
Resource Identification Initiative To cite this cell line use: AGS-5FU-R (RRID:CVCL_B7H2)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Glu (c.101G>A); ClinVar=VCV000017584; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Ala (c.1634A>C); ClinVar=VCV000013659; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0139 (AGS)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

DOI=10.21203/rs.3.rs-1302156/v1
Chang H.J., Cho M.-H., Choi M.Y., Lee K.E.
Establishment of a 5-fluorouracil-resistant human gastric cancer cell line and exploration of its biological characteristics.
Res. Sq. 2022:1302156-1302156(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7H2
Encyclopedic resources Wikidata; Q112929199
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5