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Cellosaurus MPT-S1 (CVCL_B7GV)

[Text version]
Cell line name MPT-S1
Accession CVCL_B7GV
Resource Identification Initiative To cite this cell line use: MPT-S1 (RRID:CVCL_B7GV)
Comments Population: Chinese.
Characteristics: Established from a nude mouse xenograft.
Doubling time: 2-3 days (PubMed=35365682).
Omics: Deep exome analysis.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; 7133; KMT2D; Simple; c.6079_6082delAATT; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; 11957; MED12; Simple; p.Gly44Asp (c.131G>A); ClinVar=VCV000092220; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; 9884; RB1; Simple; c.1530_1531delAG; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; 9884; RB1; Simple; c.1588_1589delAA; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu252del (c.754_756delCTC); ClinVar=VCV000998484; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; 11998; TP53; Simple; c.750_754delinsA; Zygosity=Heterozygous (PubMed=35365682).
Disease Malignant breast phyllodes tumor (NCIt: C4504)
Phyllodes tumor of the breast (ORDO: Orphanet_180261)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): PubMed=35365682

Markers:
AmelogeninX
CSF1PO12
D1S165611,16
D2S44112
D2S133823
D3S135815,16
D5S81811
D7S82012
D8S117911,13
D10S124813,14
D12S39121
D13S3179,12
D16S53910,11
D18S5118
D19S43313.2
D21S1129,30
D22S104514
DYS3919
FGA19
Penta D9,14
Penta E11,19
TH019
TPOX8,9
vWA14,16

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Publications

PubMed=35365682; DOI=10.1038/s41523-022-00413-1
Ng D.Y.X., Li Z.-M., Lee E., Kok J.S.T., Lee J.Y., Koh J., Ng C.C.-Y., Lim A.H., Liu W., Ng S.R., Lim K.S., Huang X.X., Hong J.H., Guan P.-Y., Sim Y.-R., Thike A.A., Md Nasir N.D., Li S., Tan P.H., Teh B.T., Chan J.Y.-S.
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor.
NPJ Breast Cancer 8:44.1-44.7(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7GV
Encyclopedic resources Wikidata; Q112930125
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5