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Cellosaurus HC-04.J7 (CVCL_B7D7)

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Cell line name HC-04.J7
Accession CVCL_B7D7
Resource Identification Initiative To cite this cell line use: HC-04.J7 (RRID:CVCL_B7D7)
Comments Group: Malaria research cell line.
Problematic cell line: Possibly contaminated. Parent cell line (HC-04) has been shown to have an STR profile identical to that of Hep-G2.
Population: Caucasian.
Characteristics: Compared to the parent cell line, has an inscreased susceptibility to Plasmodium falciparum sporozoite invasion (PubMed=30891005).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Z631 (HC-04)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=30891005; DOI=10.3389/fmicb.2019.00127; PMCID=PMC6413710
Rebecca E. Tweedell, Ding-Yin Tao, Timothy Hamerly, Tanisha M. Robinson, Simon Larsen, Alexander G.B. Gronning, Alessandra M. Norris, Jonas G. King, Henry Chun-Hin Law, Jan Baumbach, Elke S. Bergmann-Leitner, Rhoel R. Dinglasan;
The selection of a hepatocyte cell line susceptible to Plasmodium falciparum sporozoite invasion that is associated with expression of glypican-3.
Front. Microbiol. 10:127.1-127.16(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7D7
Encyclopedic resources Wikidata; Q112929640
Gene expression databases ArrayExpress; E-MTAB-6919
Proteomic databases PRIDE; PXD008613
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number9