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Cellosaurus Mel Rac (CVCL_B6KA)

[Text version]
Cell line name Mel Rac
Synonyms mel Rac
Accession CVCL_B6KA
Resource Identification Initiative To cite this cell line use: Mel Rac (RRID:CVCL_B6KA)
Comments Group: Patented cell line.
Registration: Non-internationally recognized Depositary Authority, Russian Cell Culture Collection (RCCC); 710D.
Derived from site: Metastatic; Right thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (DOI=10.17650/1726-9784-2018-17-4-27-35; PubMed=28881731).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (CelloPub=CLPUB00680).
HLA typing Source: Patent=RU2402602
Class I
HLA-AA*23,26
HLA-BB*08,39
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
Publications

Patent=RU2402602
Mikhailova I.N., Baryshnikov A.Y., Demidov L.V., Kiselev S.L., Burova O.S., Morozova L.F.
Cell line of human melanoma mel Rac, applied for obtaining antitumour vaccine.
Patent number RU2402602, 27-Oct-2010

CLPUB00680
Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S., Shubina I.Z., Kovalevsky D.A., Voronina E.S., Treshalina H.M., Lushnikova A.A., Tsyganova I.V., Mazurenko N.N.
Human skin melanoma cell lines collection.
(In) Management of malignant melanoma; pp.1-6; SM Group; Dover (2016)

PubMed=28881731; DOI=10.18632/oncotarget.17014
Emelyanova M., Ghukasyan L., Abramov I., Ryabaya O., Stepanova E.V., Kudryavtseva A., Sadritdinova A., Dzhumakova C., Belysheva T., Surzhikov S., Lyubchenko L., Zasedatelev A., Nasedkina T.
Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis.
Oncotarget 8:52304-52320(2017)

DOI=10.17650/1726-9784-2018-17-4-27-35
Mikhailova I.N., Treshalina E.M., Morozova L.F., Andronova N.V., Shubina I.Z., Lushnikova A.A.
Cell lines of human melanoma and their xenograft with BRAF or NRAS mutations a targets for targeted therapy.
Ross. Bioterap. Zh. 17:27-35(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B6KA
Encyclopedic resources Wikidata; Q112129308
Entry history
Entry creation17-Mar-2022
Last entry update05-Oct-2023
Version number5