ID   Mel Rac
AC   CVCL_B6KA
SY   mel Rac
DR   cancercelllines; CVCL_B6KA
DR   Wikidata; Q112129308
RX   CelloPub=CLPUB00680;
RX   DOI=10.17650/1726-9784-2018-17-4-27-35;
RX   Patent=RU2402602;
RX   PubMed=28881731;
CC   Group: Patented cell line.
CC   Registration: Non-internationally recognized Depositary Authority, Russian Cell Culture Collection (RCCC); 710D.
CC   HLA typing: A*23,26; B*08,39 (Patent=RU2402602).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (DOI=10.17650/1726-9784-2018-17-4-27-35; PubMed=28881731).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (CelloPub=CLPUB00680).
CC   Derived from site: Metastatic; Right thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
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RX   CelloPub=CLPUB00680;
RA   Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S.,
RA   Shubina I.Z., Kovalevsky D.A., Voronina E.S., Treshalina H.M.,
RA   Lushnikova A.A., Tsyganova I.V., Mazurenko N.N.;
RT   "Human skin melanoma cell lines collection.";
RL   (In) Management of malignant melanoma; pp.1-6; SM Group; Dover (2016).
//
RX   DOI=10.17650/1726-9784-2018-17-4-27-35;
RA   Mikhailova I.N., Treshalina E.M., Morozova L.F., Andronova N.V.,
RA   Shubina I.Z., Lushnikova A.A.;
RT   "Cell lines of human melanoma and their xenograft with BRAF or NRAS
RT   mutations a targets for targeted therapy.";
RL   Ross. Bioterap. Zh. 17:27-35(2018).
//
RX   Patent=RU2402602;
RA   Mikhailova I.N., Baryshnikov A.Y., Demidov L.V., Kiselev S.L.,
RA   Burova O.S., Morozova L.F.;
RT   "Cell line of human melanoma mel Rac, applied for obtaining
RT   antitumour vaccine.";
RL   Patent number RU2402602, 27-Oct-2010.
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RX   PubMed=28881731; DOI=10.18632/oncotarget.17014;
RA   Emelyanova M., Ghukasyan L., Abramov I., Ryabaya O., Stepanova E.V.,
RA   Kudryavtseva A., Sadritdinova A., Dzhumakova C., Belysheva T.,
RA   Surzhikov S., Lyubchenko L., Zasedatelev A., Nasedkina T.;
RT   "Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in
RT   Russian melanoma patients using LNA PCR clamp and biochip analysis.";
RL   Oncotarget 8:52304-52320(2017).
//