Cellosaurus Hepa/HS (CVCL_B5ZG)
Cell line name | Hepa/HS |
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Accession | CVCL_B5ZG |
Resource Identification Initiative | To cite this cell line use: Hepa/HS (RRID:CVCL_B5ZG) |
Comments | Characteristics: When doxycycline-induced overexpresses 8 liver-enriched transcription factors (LETFs) (from parent cell line). Characteristics: The parent cell line was modified to enable switching between proliferation and expression of proteins for liver function in response to heat by introducing a new heat-inducible gene expression/amplification system (pHSP-tTA-TRE-tTA-pEF1a-Puro) which was transferred using a PiggyBac transposon vector (PubMed=34149171). Transfected with: MGI; MGI:99480; Cebpa. Transfected with: MGI; MGI:88373; Cebpb. Transfected with: MGI; MGI:104982; Cebpg. Transfected with: MGI; MGI:1347476; Foxa2. Transfected with: MGI; MGI:98504; Hnf1a. Transfected with: MGI; MGI:98505; Hnf1b. Transfected with: MGI; MGI:109128; Hnf4a. Transfected with: MGI; MGI:1196423; Onecut1. Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR). Omics: Transcriptome analysis by microarray. Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
Disease | Hepatocellular carcinoma of the mouse (NCIt: C38756) |
Species of origin | Mus musculus (Mouse) (NCBI Taxonomy: 10090) |
Hierarchy | Parent: CVCL_RI52 (Hepa/8F5) |
Sex of cell | Female |
Category | Cancer cell line |
Publications | PubMed=34149171; DOI=10.1007/s10616-021-00457-4 |
Cross-references | |
Encyclopedic resources | Wikidata; Q111733353 |
Entry history | |
Entry creation | 17-Mar-2022 |
Last entry update | 29-Jun-2023 |
Version number | 4 |