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Cellosaurus Hepc/2D6.39 (CVCL_B5W2)

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Cell line name Hepc/2D6.39
Accession CVCL_B5W2
Resource Identification Initiative To cite this cell line use: Hepc/2D6.39 (RRID:CVCL_B5W2)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2625; CYP2D6.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=11377097; DOI=10.1016/S0887-2333(01)00011-x
Sumie Yoshitomi, Keiko Ikemoto, Junko Takahashi, Hiroshi Miki, Masayoshi Namba, Satoru Asahi;
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.
Toxicol. In Vitro 15:245-256(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B5W2
Encyclopedic resources Wikidata; Q111733389
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number8