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Cellosaurus MCF7-FGFR1 (CVCL_B5PF)

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Cell line name MCF7-FGFR1
Synonyms MCF7-R1
Accession CVCL_B5PF
Resource Identification Initiative To cite this cell line use: MCF7-FGFR1 (RRID:CVCL_B5PF)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3688; FGFR1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages Provider; I2B; P-101; http://inven2biologics.com/shop/cell-lines/human/mcf7-fgfr1-breast-cancer-cell-line-0
Publications

PubMed=34542998; DOI=10.1021/acs.biomac.1c00662; PMCID=PMC8512659
Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Vigdis Sorensen, Geir Frode Oy, Skjalg Brunheim, Ellen Margrethe Haugsten, Gunhild Mari Maelandsmo, Anthoni Wiedlocha, Jacek Otlewski;
Fibroblast growth factor 2 conjugated with monomethyl auristatin e inhibits tumor growth in a mouse model.
Biomacromolecules 22:4169-4180(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B5PF
Encyclopedic resources Wikidata; Q112930094
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number9