Cellosaurus cell line (CVCL

Cellosaurus (CVCL_B5EC)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JWGray breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Asian.
Doubling time: ~70 hours (DSMZ=ACC-440); 99.85 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.

Sequence variations

Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ser1461Profs*2 (c.4381delT); Zygosity=Heterozygous (Cosmic-CLP=910852; DepMap=ACH-000857).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Heterozygous (Cosmic-CLP=910852; DepMap=ACH-000857).

HLA typing

Source: PubMed=26589293

Class I
HLA-A	A*03:01,03:01
HLA-B	B*50:01,67:02
HLA-C	C*06:02,12:02

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.83
Native American	0
East Asian, North	4.79
East Asian, South	0
South Asian	87.38
European, North	0
European, South	7

Disease

Breast carcinoma (NCIt: C4872)

Species of origin

Carassius auratus (Goldfish) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_B7MJ ! CAL-85-2

Sex of cell

Female

Age at sampling

35Y

Category

Cancer cell line

STR profile

Source(s): Cosmic-CLP=910852; DSMZ=ACC-440; PubMed=25877200

Markers:

Amelogenin	X
CSF1PO	12
D13S317	11
D16S539	11,13
D18S51	14
D19S433	15
D21S11	30.2,32.2
D2S1338	20
D3S1358	16
D5S818	11
D7S820	9,10
D8S1179	15
FGA	24
Penta D	9
Penta E	11
TH01	6
TPOX	8,11
vWA	18

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255

Publications

switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

literature.
Cancer Res. 77:2784-2788(2017)

Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number