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Cellosaurus ciChEnC (CVCL_B4IC)

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Cell line name ciChEnC
Synonyms conditionally immortalized Choroidal Endothelial Cell
Accession CVCL_B4IC
Resource Identification Initiative To cite this cell line use: ciChEnC (RRID:CVCL_B4IC)
Comments Characteristics: Can be maintained in culture at the permissive temperature of 33 Celsius for up to 27 passages without signs of senescence.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Eye, choroid; UBERON=UBERON_0001776.
Cell type: Endothelial cell; CL=CL_0000115.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Conditionally immortalized cell line
Publications

PubMed=29392318; DOI=10.1167/iovs.IOVS-17-22893
Markus A. Loeven, Jasper J. van Gemst, Carolien M.S. Schophuizen, Viranga Tilakaratna, Lambertus P.W.J. van den Heuvel, Anthony John Day, B. Jeroen Klevering, Johan van der Vlag;
A novel choroidal endothelial cell line has a decreased affinity for the age-related macular degeneration-associated complement factor H variant 402H.
Invest. Ophthalmol. Vis. Sci. 59:722-730(2018)

Cross-references
Encyclopedic resources Wikidata; Q110432722
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number10