ID   ciChEnC
AC   CVCL_B4IC
SY   conditionally immortalized Choroidal Endothelial Cell
DR   Wikidata; Q110432722
RX   PubMed=29392318;
CC   Characteristics: Can be maintained in culture at the permissive temperature of 33 Celsius for up to 27 passages without signs of senescence.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Eye, choroid; UBERON=UBERON_0001776.
CC   Cell type: Endothelial cell; CL=CL_0000115.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   63Y
CA   Conditionally immortalized cell line
DT   Created: 16-12-21; Last updated: 14-08-25; Version: 10
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RX   PubMed=29392318; DOI=10.1167/iovs.IOVS-17-22893;
RA   Loeven, Markus A.
RA   van Gemst, Jasper J.
RA   Schophuizen, Carolien M.S.
RA   Tilakaratna, Viranga
RA   van den Heuvel, Lambertus P.W.J.
RA   Day, Anthony John
RA   Klevering, B. Jeroen
RA   van der Vlag, Johan
RT   "A novel choroidal endothelial cell line has a decreased affinity for
RT   the age-related macular degeneration-associated complement factor H
RT   variant 402H.";
RL   Invest. Ophthalmol. Vis. Sci. 59:722-730(2018).
//