Cellosaurus logo
expasy logo

Cellosaurus TL-Om1 (CVCL_B473)

[Text version]
Cell line name TL-Om1
Synonyms TL-om1; TL-OM1; TLom1; TLOM1; TL-OML
Accession CVCL_B473
Resource Identification Initiative To cite this cell line use: TL-Om1 (RRID:CVCL_B473)
Comments Population: Japanese.
Biotechnology: Used as a reference cell line to standardize the qPCR of HTLV-1 (PubMed=25502533; PubMed=30125970).
Characteristics: IL2 dependent.
Virology: The HTLV-1 provirus is monoclonally integrated in chromosome 1 (PubMed=25502533).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=6088403; DOI=10.1002/ijc.2910340213
Sugamura K., Fujii M., Kannagi M., Sakitani M., Takeuchi M., Hinuma Y.
Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus.
Int. J. Cancer 34:221-228(1984)

PubMed=2981920; DOI=10.4049/jimmunol.134.3.1728
Shimizu K., Hirano T., Ishibashi K., Nakano N., Taga T., Sugamura K., Yamamura Y., Kishimoto T.
Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by human T cell leukemia virus (HTLV) and characterization of human BGDF (BCGF II).
J. Immunol. 134:1728-1733(1985)

PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350
Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K., Hattori T., Yamabe H., Okuma M., Uchiyama T.
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Blood 86:2350-2357(1995)

PubMed=10706122
Nosaka K., Maeda M., Tamiya S., Sakai T., Mitsuya H., Matsuoka M.
Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia.
Cancer Res. 60:1043-1048(2000)

PubMed=25502533; DOI=10.1128/jcm.02254-14
Kuramitsu M., Okuma K., Yamagishi M., Yamochi T., Firouzi S., Momose H., Mizukami T., Takizawa K., Araki K., Sugamura K., Yamaguchi K., Watanabe T., Hamaguchi I.
Identification of TL-Om1, an adult T-cell leukemia (ATL) cell line, as reference material for quantitative PCR for human T-lymphotropic virus 1.
J. Clin. Microbiol. 53:587-596(2015)

PubMed=30125970; DOI=10.1111/1348-0421.12644
Kuramitsu M., Okuma K., Nakashima M., Sato T., Sasaki D., Hasegawa H., Umeki K., Kubota R., Sasada K., Sobata R., Matsumoto C., Kaneko N., Tezuka K., Matsuoka S., Utsunomiya A., Koh K.-R., Ogata M., Ishitsuka K., Taki M., Nosaka K., Uchimaru K., Iwanaga M., Sagara Y., Yamano Y., Okayama A., Miura K., Satake M., Saito S., Watanabe T., Hamaguchi I.
Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan.
Microbiol. Immunol. 62:673-676(2018)

Cross-references
Cell line collections (Providers) RCB; RCB2086 - Discontinued
TKG; TKG 0289
Encyclopedic resources Wikidata; Q54972603
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number17