ID   TL-Om1
AC   CVCL_B473
SY   TL-om1; TL-OM1; TLom1; TLOM1; TL-OML
DR   RCB; RCB2086
DR   TKG; TKG 0289
DR   Wikidata; Q54972603
RX   PubMed=2981920;
RX   PubMed=6088403;
RX   PubMed=7662981;
RX   PubMed=10706122;
RX   PubMed=25502533;
RX   PubMed=30125970;
CC   Population: Japanese.
CC   Biotechnology: Used as a reference cell line to standardize the qPCR of HTLV-1 (PubMed=25502533; PubMed=30125970).
CC   Characteristics: IL2 dependent.
CC   Virology: The HTLV-1 provirus is monoclonally integrated in chromosome 1 (PubMed=25502533).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Discontinued: RCB; RCB2086; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 17
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RX   PubMed=2981920; DOI=10.4049/jimmunol.134.3.1728;
RA   Shimizu K., Hirano T., Ishibashi K., Nakano N., Taga T., Sugamura K.,
RA   Yamamura Y., Kishimoto T.;
RT   "Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by
RT   human T cell leukemia virus (HTLV) and characterization of human BGDF
RT   (BCGF II).";
RL   J. Immunol. 134:1728-1733(1985).
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RX   PubMed=6088403; DOI=10.1002/ijc.2910340213;
RA   Sugamura K., Fujii M., Kannagi M., Sakitani M., Takeuchi M.,
RA   Hinuma Y.;
RT   "Cell surface phenotypes and expression of viral antigens of various
RT   human cell lines carrying human T-cell leukemia virus.";
RL   Int. J. Cancer 34:221-228(1984).
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RX   PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350;
RA   Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K.,
RA   Hattori T., Yamabe H., Okuma M., Uchiyama T.;
RT   "Tumorigenicity of human T-cell leukemia virus type I-infected cell
RT   lines in severe combined immunodeficient mice and characterization of
RT   the cells proliferating in vivo.";
RL   Blood 86:2350-2357(1995).
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RX   PubMed=10706122;
RA   Nosaka K., Maeda M., Tamiya S., Sakai T., Mitsuya H., Matsuoka M.;
RT   "Increasing methylation of the CDKN2A gene is associated with the
RT   progression of adult T-cell leukemia.";
RL   Cancer Res. 60:1043-1048(2000).
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RX   PubMed=25502533; DOI=10.1128/jcm.02254-14; PMCID=PMC4298509;
RA   Kuramitsu M., Okuma K., Yamagishi M., Yamochi T., Firouzi S.,
RA   Momose H., Mizukami T., Takizawa K., Araki K., Sugamura K.,
RA   Yamaguchi K., Watanabe T., Hamaguchi I.;
RT   "Identification of TL-Om1, an adult T-cell leukemia (ATL) cell line,
RT   as reference material for quantitative PCR for human T-lymphotropic
RT   virus 1.";
RL   J. Clin. Microbiol. 53:587-596(2015).
//
RX   PubMed=30125970; DOI=10.1111/1348-0421.12644;
RA   Kuramitsu M., Okuma K., Nakashima M., Sato T., Sasaki D., Hasegawa H.,
RA   Umeki K., Kubota R., Sasada K., Sobata R., Matsumoto C., Kaneko N.,
RA   Tezuka K., Matsuoka S., Utsunomiya A., Koh K.-R., Ogata M.,
RA   Ishitsuka K., Taki M., Nosaka K., Uchimaru K., Iwanaga M., Sagara Y.,
RA   Yamano Y., Okayama A., Miura K., Satake M., Saito S., Watanabe T.,
RA   Hamaguchi I.;
RT   "Development of reference material with assigned value for human
RT   T-cell leukemia virus type 1 quantitative PCR in Japan.";
RL   Microbiol. Immunol. 62:673-676(2018).
//