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Cellosaurus SKOV3/MRP7 (CVCL_B3Q0)

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Cell line name SKOV3/MRP7
Accession CVCL_B3Q0
Resource Identification Initiative To cite this cell line use: SKOV3/MRP7 (RRID:CVCL_B3Q0)
Comments Population: Caucasian.
Doubling time: 68.19 +- 1.53 hours (PubMed=34631561).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:52; ABCC10.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=34631561; DOI=10.3389/fonc.2021.731260; PMCID=PMC8498192
Jing-Quan Wang, Zhuo-Xun Wu, Yuqi Yang, Jin-Sui Li, Dong-Hua Yang, Ying-Fang Fan, Zhe-Sheng Chen;
Establishment and characterization of a novel multidrug resistant human ovarian cancer cell line with heterogenous MRP7 overexpression.
Front. Oncol. 11:731260.1-731260.10(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B3Q0
Encyclopedic resources Wikidata; Q110433238
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number8