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Cellosaurus HeLa-ACE2-TMPRSS2 (CVCL_B3LV)

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Cell line name HeLa-ACE2-TMPRSS2
Accession CVCL_B3LV
Resource Identification Initiative To cite this cell line use: HeLa-ACE2-TMPRSS2 (RRID:CVCL_B3LV)
Comments Population: African American.
Virology: Can be used to isolate human coronavirus NL63 (HCoV-NL63) (JCRB=JCRB1835).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11876; TMPRSS2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1276 (HeLa 229)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1835

Markers:
AmelogeninX
CSF1PO10
D5S81811,12
D7S8208,12,13
D13S31713.3,14.3
D16S5399,10
TH017
TPOX8,12
vWA16,18,19

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Publications

PubMed=22496216; DOI=10.1128/JVI.00094-12; PMCID=PMC3393535
Miyuki Kawase, Kazuya Shirato, Lia van der Hoek, Fumihiro Taguchi, Shutoku Matsuyama;
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
J. Virol. 86:6537-6545(2012)

Cross-references
Cell line collections (Providers) JCRB; JCRB1835
Encyclopedic resources Wikidata; Q110432868
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number11