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Cellosaurus NAN-3 (CVCL_B318)

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Cell line name NAN-3
Synonyms NAN3
Accession CVCL_B318
Resource Identification Initiative To cite this cell line use: NAN-3 (RRID:CVCL_B318)
Comments Characteristics: Produces IgA kappa.
Characteristics: IL6 dependent.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Miscellaneous: Age at sampling and HLA typing from personal communication of Pellat-Deceunynck, Catherine.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248insGln (c.744insCAG); Zygosity=Unspecified (PubMed=21173094).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*01,02
HLA-BB*08,40
HLA-CC*03,07
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=16638930; DOI=10.1182/blood-2005-12-007971
Emmanuelle Menoret, Patricia Gomez-Bougie, Alexandrine Geffroy-Luseau, Sylvanne Daniels, Philippe Moreau, Steven Le Gouill, Jean-Luc Harousseau, Francois-Regis Bataille, Martine Amiot, Catherine Pellat-Deceunynck;
Mcl-1L cleavage is involved in TRAIL-R1- and TRAIL-R2-mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells.
Blood 108:1346-1352(2006)

PubMed=16956823
Francois-Regis Bataille, Gaatan Jego, Nelly Robillard, Sophie Barille-Nion, Jean-Luc Harousseau, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck;
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)

PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235
Jerome Moreaux, Bernard Klein, Francois-Regis Bataille, Geraldine Descamps, Sophie Maiga, Dirk Hose, Hartmut Goldschmidt, Anna Jauch, Thierry Reme, Michel Jourdan, Martine Amiot, Catherine Pellat-Deceunynck;
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660
Benoit Tessoulin, Agnes Moreau-Aubry, Geraldine Descamps, Patricia Gomez-Bougie, Sophie Maiga, Alban Gaignard, David Chiron, Emmanuelle Menoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck;
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

Cross-references
Encyclopedic resources Wikidata; Q54907476
Gene expression databases ArrayExpress; E-TABM-1088
Polymorphism and mutation databases Cosmic; 2809780
IARC_TP53; 28516
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number20