ID   NAN-3
AC   CVCL_B318
SY   NAN3
DR   ArrayExpress; E-TABM-1088
DR   Cosmic; 2809780
DR   IARC_TP53; 28516
DR   Wikidata; Q54907476
RX   PubMed=16638930;
RX   PubMed=16956823;
RX   PubMed=21173094;
RX   PubMed=30545397;
WW   Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
CC   Characteristics: Produces IgA kappa.
CC   Characteristics: IL6 dependent.
CC   HLA typing: A*01,02; B*08,40; C*03,07 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248insGln (c.744insCAG); Zygosity=Unspecified (PubMed=21173094).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Miscellaneous: Age at sampling and HLA typing from personal communication of Pellat-Deceunynck, Catherine.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   60Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 19
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RX   PubMed=16638930; DOI=10.1182/blood-2005-12-007971;
RA   Menoret E., Gomez-Bougie P., Geffroy-Luseau A., Daniels S., Moreau P.,
RA   Le Gouill S., Harousseau J.-L., Bataille F.-R., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Mcl-1L cleavage is involved in TRAIL-R1- and TRAIL-R2-mediated
RT   apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma
RT   cells.";
RL   Blood 108:1346-1352(2006).
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RX   PubMed=16956823;
RA   Bataille F.-R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L.,
RA   Moreau P., Amiot M., Pellat-Deceunynck C.;
RT   "The phenotype of normal, reactive and malignant plasma cells.
RT   Identification of 'many and multiple myelomas' and of new targets for
RT   myeloma therapy.";
RL   Haematologica 91:1234-1240(2006).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235;
RA   Moreaux J., Klein B., Bataille F.-R., Descamps G., Maiga S., Hose D.,
RA   Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
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RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660;
RA   Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S.,
RA   Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137.1-137.13(2018).
//