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Cellosaurus MEC (CVCL_B270)

[Text version]
Cell line name MEC
Accession CVCL_B270
Resource Identification Initiative To cite this cell line use: MEC (RRID:CVCL_B270)
Comments Population: Japanese.
Doubling time: 40.8 hours (PubMed=1965684).
Omics: Phenotyping; CRISPR screening.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2129; TKG=TKG 0629

Markers:
AmelogeninX,Y
CSF1PO10,14
D5S81811,13
D7S8209.3,11 (TKG=TKG 0629)
11 (RCB=RCB2129)
D13S3178,11 (RCB=RCB2129)
9,11 (TKG=TKG 0629)
D16S5399,12
TH019.3
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1965684
Koichi Yoshida, Hiromi Tomizawa, Tomohiko Ota, Takashi Nagashima, Hideki Kikuchi, Hiromu Watanabe, Kazuko Hashizaki, Asahide Yonaha;
Establishment and characterization of human cholangiocarcinoma, MEC, producing carbohydrate antigen 19-9.
Hum. Cell 3:346-351(1990)

PubMed=21451941; DOI=10.1007/s00534-011-0376-7
Jun Sato, Takashi Kimura, Takuro Saito, Takayuki Anazawa, Akira Kenjo, Yoshihiro Sato, Takao Tsuchiya, Mitsukazu Gotoh;
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J. Hepatobiliary Pancreat. Sci. 18:700-711(2011)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=36724073; DOI=10.1016/j.celrep.2023.112065
Ji-Cheng Yang, Fu-Sheng Guo, Hui-San Chin, Gao-Bin Chen, Chow-Hiang Ang, Qing-Song Lin, Wan-Jin Hong, Nai-Yang Fu;
Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.
Cell Rep. 42:112065.1-112065.26(2023)

Cross-references
Cell line collections (Providers) RCB; RCB2129 - Discontinued
TKG; TKG 0629 - Discontinued
Biological sample resources BioSample; SAMN03472009
CRISP screens repositories BioGRID_ORCS_Cell_line; 1788
Encyclopedic resources Wikidata; Q54904994
Polymorphism and mutation databases Cosmic; 1122351
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number22