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Cellosaurus PC/AA (CVCL_B261)

[Text version]
Cell line name PC/AA
Synonyms AA
Accession CVCL_B261
Resource Identification Initiative To cite this cell line use: PC/AA (RRID:CVCL_B261)
Comments Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=2253215).
Disease Colorectal adenoma (NCIt: C5673)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ04 (PC/AA/C1)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
Publications

PubMed=6746117; DOI=10.1002/ijc.2910340109
Paraskeva C., Buckle B.G., Sheer D., Wigley C.B.
The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients.
Int. J. Cancer 34:49-56(1984)

DOI=10.1007/978-1-4612-0411-4_28
Williams A.C., Manning A., Harper S.J., Paraskeva C.
Multiple steps in the in vitro immortalisation and neoplastic conversion of human colonic epithelial cells.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.281-290; Humana Press; New York (1990)

PubMed=2253215
Baker S.J., Preisinger A.C., Jessup J.M., Paraskeva C., Markowitz S.D., Willson J.K.V., Hamilton S.R., Vogelstein B.
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
Cancer Res. 50:7717-7722(1990)

PubMed=2369746
Williams A.C., Harper S.J., Paraskeva C.
Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.
Cancer Res. 50:4724-4730(1990)

Cross-references
Encyclopedic resources Wikidata; Q54938513
Polymorphism and mutation databases IARC_TP53; 23785
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number11