ID   PC/AA
AC   CVCL_B261
SY   AA
DR   IARC_TP53; 23785
DR   Wikidata; Q54938513
RX   DOI=10.1007/978-1-4612-0411-4_28;
RX   PubMed=2253215;
RX   PubMed=2369746;
RX   PubMed=6746117;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=2253215).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C5673; Colorectal adenoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 11
//
RX   DOI=10.1007/978-1-4612-0411-4_28;
RA   Williams A.C., Manning A., Harper S.J., Paraskeva C.;
RT   "Multiple steps in the in vitro immortalisation and neoplastic
RT   conversion of human colonic epithelial cells.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.281-290; Humana Press; New York (1990).
//
RX   PubMed=2253215;
RA   Baker S.J., Preisinger A.C., Jessup J.M., Paraskeva C., Markowitz S.D.,
RA   Willson J.K.V., Hamilton S.R., Vogelstein B.;
RT   "p53 gene mutations occur in combination with 17p allelic deletions as
RT   late events in colorectal tumorigenesis.";
RL   Cancer Res. 50:7717-7722(1990).
//
RX   PubMed=2369746;
RA   Williams A.C., Harper S.J., Paraskeva C.;
RT   "Neoplastic transformation of a human colonic epithelial cell line: in
RT   vitro evidence for the adenoma to carcinoma sequence.";
RL   Cancer Res. 50:4724-4730(1990).
//
RX   PubMed=6746117; DOI=10.1002/ijc.2910340109;
RA   Paraskeva C., Buckle B.G., Sheer D., Wigley C.B.;
RT   "The isolation and characterization of colorectal epithelial cell
RT   lines at different stages in malignant transformation from familial
RT   polyposis coli patients.";
RL   Int. J. Cancer 34:49-56(1984).
//