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Cellosaurus UM-RC-5 (CVCL_B227)

[Text version]
Cell line name UM-RC-5
Synonyms UMRC-5; UMRC5; University of Michigan-Renal Carcinoma-5
Accession CVCL_B227
Resource Identification Initiative To cite this cell line use: UM-RC-5 (RRID:CVCL_B227)
Comments Doubling time: ~43 hours (PubMed=4038766).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 12687; VHL; Simple; p.Tyr175Serfs*27 (c.524delA); Zygosity=Unspecified (PubMed=7915601; PubMed=8493574).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=4038766; DOI=10.1002/jso.2930280320
Grossman H.B., Wedemeyer G., Ren L.-Q.
Human renal carcinoma: characterization of five new cell lines.
J. Surg. Oncol. 28:237-244(1985)

PubMed=8493574; DOI=10.1126/science.8493574
Latif F., Tory K., Gnarra J.R., Yao M., Duh F.-M., Orcutt M.L., Stackhouse T., Kuzmin I.A., Modi W., Geil L., Schmidt L.S., Zhou F.-W., Li H., Wei M.H., Chen F., Glenn G., Choyke P., Walther M.M., Weng Y.-K., Duan D.-S.R., Dean M., Glavac D., Richards F.M., Crossey P.A., Ferguson-Smith M.A., Le Paslier D., Chumakov I., Cohen D., Chinault A.C., Maher E.R., Linehan W.M., Zbar B., Lerman M.I.
Identification of the von Hippel-Lindau disease tumor suppressor gene.
Science 260:1317-1320(1993)

PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)

Cross-references
Encyclopedic resources Wikidata; Q54990785
Polymorphism and mutation databases Cosmic; 972872
Cosmic; 972912
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number13