ID   UM-RC-5
AC   CVCL_B227
SY   UMRC-5; UMRC5; University of Michigan-Renal Carcinoma-5
DR   Cosmic; 972872
DR   Cosmic; 972912
DR   Wikidata; Q54990785
RX   PubMed=4038766;
RX   PubMed=7915601;
RX   PubMed=8493574;
CC   Doubling time: ~43 hours (PubMed=4038766).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Tyr175Serfs*27 (c.524delA); Zygosity=Unspecified (PubMed=7915601; PubMed=8493574).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 13
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RX   PubMed=4038766; DOI=10.1002/jso.2930280320;
RA   Grossman H.B., Wedemeyer G., Ren L.-Q.;
RT   "Human renal carcinoma: characterization of five new cell lines.";
RL   J. Surg. Oncol. 28:237-244(1985).
//
RX   PubMed=7915601; DOI=10.1038/ng0594-85;
RA   Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F.,
RA   Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C.,
RA   Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H.,
RA   Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B.,
RA   Linehan W.M.;
RT   "Mutations of the VHL tumour suppressor gene in renal carcinoma.";
RL   Nat. Genet. 7:85-90(1994).
//
RX   PubMed=8493574; DOI=10.1126/science.8493574;
RA   Latif F., Tory K., Gnarra J.R., Yao M., Duh F.-M., Orcutt M.L.,
RA   Stackhouse T., Kuzmin I.A., Modi W., Geil L., Schmidt L.S., Zhou F.-W.,
RA   Li H., Wei M.H., Chen F., Glenn G., Choyke P., Walther M.M., Weng Y.-K.,
RA   Duan D.-S.R., Dean M., Glavac D., Richards F.M., Crossey P.A.,
RA   Ferguson-Smith M.A., Le Paslier D., Chumakov I., Cohen D.,
RA   Chinault A.C., Maher E.R., Linehan W.M., Zbar B., Lerman M.I.;
RT   "Identification of the von Hippel-Lindau disease tumor suppressor
RT   gene.";
RL   Science 260:1317-1320(1993).
//