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Cellosaurus A375-M (CVCL_B222)

[Text version]
Cell line name A375-M
Synonyms A375M; A375m
Accession CVCL_B222
Resource Identification Initiative To cite this cell line use: A375-M (RRID:CVCL_B222)
Comments Population: Caucasian.
Characteristics: Metastatic variant of A-375. Established from a tumor obtained in nude mice injected with the parent cell line.
Omics: Exosome proteome analysis.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line

Kozlowski J.M., Fidler I.J., Campbell D., Xu Z.-L., Kaighn M.E., Hart I.R.
Metastatic behavior of human tumor cell lines grown in the nude mouse.
Cancer Res. 44:3522-3529(1984)

PubMed=2731157; DOI=10.1016/0304-3835(89)90148-1
Yohem K.H., Seftor E.A., Meyskens F.L. Jr., Hendrix M.J.C.
Cloning efficiency of human melanoma cells is modulated after invasion through a reconstituted basement membrane.
Cancer Lett. 45:135-143(1989)

PubMed=1671030; DOI=10.1002/ijc.2910470211
Welch D.R., Bisi J.E., Miller B.E., Conaway D.H., Seftor E.A., Yohem K.H., Gilmore L.B., Seftor R.E.B., Nakajima M., Hendrix M.J.C.
Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.
Int. J. Cancer 47:227-237(1991)

PubMed=7648437; DOI=10.1089/jir.1995.15.81
Singh R.K., Gutman M., Radinsky R.
Heterogeneity of cytokine and growth factor gene expression in human melanoma cells with different metastatic potentials.
J. Interferon Cytokine Res. 15:81-87(1995)

Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A., Toso R.J., Herlyn M., Bennett D.C.
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)

PubMed=25950383; DOI=10.1111/pcmr.12380
Lazar I., Clement E., Ducoux-Petit M., Denat L., Soldan V., Dauvillier S., Balor S., Burlet-Schiltz O., Larue L., Muller C., Nieto L.
Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines.
Pigment Cell Melanoma Res. 28:464-475(2015)

Cell line databases/resources cancercelllines; CVCL_B222
Encyclopedic resources Wikidata; Q54606798
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number21