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Cellosaurus MRC5/ACE2 (CVCL_B0XS)

[Text version]
Cell line name MRC5/ACE2
Accession CVCL_B0XS
Resource Identification Initiative To cite this cell line use: MRC5/ACE2 (RRID:CVCL_B0XS)
Comments Group: SARS-CoV-2 research cell line.
Virology: Highly susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33686154).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0440 (MRC-5)
Sex of cell Male
Age at sampling 14FW
Category Finite cell line
Publications

PubMed=33686154; DOI=10.1038/s41598-021-84882-7; PMCID=PMC7940632
Kentaro Uemura, Michihito Sasaki, Takao Sanaki, Shinsuke Toba, Yoshimasa Takahashi, Yasuko Orba, William W. Hall, Katsumi Maenaka, Hirofumi Sawa, Akihiko Sato;
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.
Sci. Rep. 11:5376.1-5376.9(2021)

Cross-references
Encyclopedic resources Wikidata; Q108820962
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number9