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Cellosaurus NIKS-16 (CVCL_B0UM)

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Cell line name NIKS-16
Synonyms NIKS16; BC-1-Ep/SL/HPV-16
Accession CVCL_B0UM
Resource Identification Initiative To cite this cell line use: NIKS-16 (RRID:CVCL_B0UM)
Comments Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A1LW (NIKS)
Sex of cell Male
Age at sampling <1M
Category Transformed cell line
Publications

PubMed=10864676; DOI=10.1128/JVI.74.14.6622-6631.2000; PMCID=PMC112172
Elsa Renee Flores, B. Lynn Allen-Hoffmann, Denis L. Lee, Paul F. Lambert;
The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle.
J. Virol. 74:6622-6631(2000)

PubMed=28623356; DOI=10.1038/s41598-017-03295-7; PMCID=PMC5473897
Louis Cicchini, Rachel Z. Blumhagen, Joseph A. Westrich, Mallory E. Myers, Cody Jay Warren, Charlotte Siska, David Raben, Katerina Joanna Kechris, Dohun Pyeon;
High-risk human papillomavirus E7 alters host DNA methylome and represses HLA-E expression in human keratinocytes.
Sci. Rep. 7:3633.1-3633.13(2017)

PubMed=29021401; DOI=10.1128/JVI.01001-17; PMCID=PMC5709591
Tanya Klymenko, Quan Gu, Imogen Herbert, Andy Stevenson, Victor Iliev, G. Watkins, Cameron Stuart Pollock, Ramya Bhatia, Kate Cuschieri, Pawel Herzyk, Derek Gatherer, Sheila V. Graham;
RNA-Seq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus 16 infection, including loss of epithelial barrier function.
J. Virol. 91:e01001.17.1-e01001.17.17(2017)

Cross-references
Encyclopedic resources Wikidata; Q108821045
Gene expression databases GEO; GSM2197775
GEO; GSM2197776
GEO; GSM2197777
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number7