ID   NIKS-16
AC   CVCL_B0UM
SY   NIKS16; BC-1-Ep/SL/HPV-16
DR   GEO; GSM2197775
DR   GEO; GSM2197776
DR   GEO; GSM2197777
DR   Wikidata; Q108821045
RX   PubMed=10864676;
RX   PubMed=28623356;
RX   PubMed=29021401;
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A1LW ! NIKS
SX   Male
AG   <1M
CA   Transformed cell line
DT   Created: 23-09-21; Last updated: 10-04-25; Version: 6
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RX   PubMed=10864676; DOI=10.1128/JVI.74.14.6622-6631.2000; PMCID=PMC112172;
RA   Flores E.R., Allen-Hoffmann B.L., Lee D.L., Lambert P.F.;
RT   "The human papillomavirus type 16 E7 oncogene is required for the
RT   productive stage of the viral life cycle.";
RL   J. Virol. 74:6622-6631(2000).
//
RX   PubMed=28623356; DOI=10.1038/s41598-017-03295-7; PMCID=PMC5473897;
RA   Cicchini L., Blumhagen R.Z., Westrich J.A., Myers M.E., Warren C.J.,
RA   Siska C., Raben D., Kechris K.J., Pyeon D.;
RT   "High-risk human papillomavirus E7 alters host DNA methylome and
RT   represses HLA-E expression in human keratinocytes.";
RL   Sci. Rep. 7:3633-3633(2017).
//
RX   PubMed=29021401; DOI=10.1128/JVI.01001-17; PMCID=PMC5709591;
RA   Klymenko T., Gu Q., Herbert I., Stevenson A., Iliev V., Watkins G.,
RA   Pollock C.S., Bhatia R., Cuschieri K., Herzyk P., Gatherer D.,
RA   Graham S.V.;
RT   "RNA-Seq analysis of differentiated keratinocytes reveals a massive
RT   response to late events during human papillomavirus 16 infection,
RT   including loss of epithelial barrier function.";
RL   J. Virol. 91:e01001.17.1-e01001.17.17(2017).
//