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Cellosaurus 1083-17-1A (CVCL_B0T4)

[Text version]

Cell line name 1083-17-1A
Synonyms 17-1A; CO17-1A
Accession CVCL_B0T4
Resource Identification Initiative To cite this cell line use: 1083-17-1A (RRID:CVCL_B0T4)
Comments Biotechnology: Was used to produce the monoclonal antibody Edrecolomab (Panorex) which was evaluated as a therapeutic agent against stage III colorectal carcinoma. Was never approved by FDA but was used in Germany in 1995.
Monoclonal antibody isotype: IgG2a.
Monoclonal antibody target: UniProtKB; P16422; Human EPCAM/CD326.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_3411 (P3X63Ag8)
Category Hybridoma

PubMed=94699; DOI=10.1007/BF01542654
Koprowski H., Steplewski Z., Mitchell K.F., Herlyn M., Herlyn D., Fuhrer P.
Colorectal carcinoma antigens detected by hybridoma antibodies.
Somatic Cell Genet. 5:957-971(1979)

PubMed=286328; DOI=10.1073/pnas.76.3.1438
Herlyn M., Steplewski Z., Herlyn D., Koprowski H.
Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979)

PubMed=6933502; DOI=10.1073/pnas.77.8.4539
Gilliland D.G., Steplewski Z., Collier R.J., Mitchell K.F., Chang T.H., Koprowski H.
Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.
Proc. Natl. Acad. Sci. U.S.A. 77:4539-4543(1980)

PubMed=9806108; DOI=10.2165/00003495-199856040-00011
Adkins J.C., Spencer C.M.
Edrecolomab (monoclonal antibody 17-1A).
Drugs 56:619-626(1998)

Biological sample resources ABCD; ABCD_AC851
Encyclopedic resources Wikidata; Q108819344
Entry history
Entry creation23-Sep-2021
Last entry update17-Mar-2022
Version number3