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Cellosaurus H1975/OR [China Dongguan] (CVCL_B0JT)

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Cell line name H1975/OR [China Dongguan]
Accession CVCL_B0JT
Resource Identification Initiative To cite this cell line use: H1975/OR [China Dongguan] (RRID:CVCL_B0JT)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90943; Osimertinib (AZD9291).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=33992097; DOI=10.1186/s12890-021-01540-4; PMCID=PMC8126145
Ke-Jun Liu, Xian-Wen Chen, Li-Gang Wu, Shi-Yuan Chen, Nian-Xin Fang, Li-Min Cai, Jun Jia;
ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial-mesenchymal transition.
BMC Pulm. Med. 21:163.1-163.11(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B0JT
Encyclopedic resources Wikidata; Q108820355
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number5