ID   H1975/OR [China Dongguan]
AC   CVCL_B0JT
DR   cancercelllines; CVCL_B0JT
DR   Wikidata; Q108820355
RX   PubMed=33992097;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_90943; Osimertinib (AZD9291).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1511 ! NCI-H1975
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 5
//
RX   PubMed=33992097; DOI=10.1186/s12890-021-01540-4; PMCID=PMC8126145;
RA   Liu K.-J., Chen X.-W., Wu L.-G., Chen S.-Y., Fang N.-X., Cai L.-M.,
RA   Jia J.;
RT   "ID1 mediates resistance to osimertinib in EGFR T790M-positive
RT   non-small cell lung cancer through epithelial-mesenchymal
RT   transition.";
RL   BMC Pulm. Med. 21:163.1-163.11(2021).
//