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Cellosaurus ID1-V-LUC hES (CVCL_B0JB)

[Text version]
Cell line name ID1-V-LUC hES
Synonyms CGMCC11091
Accession CVCL_B0JB
Resource Identification Initiative To cite this cell line use: ID1-V-LUC hES (RRID:CVCL_B0JB)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China General Microbiological Culture Collection Center; CGMCC No.11091.
Characteristics: Stem cell model for screening drugs for pulmonary hypertension and to find a novel lead compound for the treatment of pulmonary hypertension using BMP signaling.
Characteristics: Transduced with a Id1-Venus-Luc-MC1-DTA construct in which expression of the genes for Venus and luciferase are under the control of a full-length human ID1 promoter.
Genetic integration: Method=Transduction; Gene=FPbase; YUJWJ; Venus (Note=Bright yellow fluorescent protein derived from GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9773 (WA09)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

Patent=US20180172669
Jun Yang, Fang Zhou, Shi-Qiang Gong, Qing-Xia Wei, Shuang Zhao, Shu-Yi Si;
Screening and use of piperidino pyrazolopyrimidine compound.
Patent number US20180172669, 21-Jun-2018

PubMed=29449428; DOI=10.1183/13993003.02229-2017
Yan-Jiang Xing, Shuang Zhao, Qing-Xia Wei, Shi-Qiang Gong, Xin Zhao, Fang Zhou, Rafia Al-Lamki, Daniel Ortmann, Ming-Xia Du, Roger Arnold Pedersen, Guang-Dong Shang ...Show all 14 authors... , Shu-Yi Si, Nicholas W. Morrell, Jun Yang; Show fewer authors
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.
Eur. Respir. J. 51:1702229-1702229(2018)

Cross-references
Encyclopedic resources Wikidata; Q108820530
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number8