Cellosaurus logo
expasy logo

Cellosaurus Z-138 (CVCL_B077)

[Text version]
Cell line name Z-138
Synonyms Z138
Accession CVCL_B077
Resource Identification Initiative To cite this cell line use: Z-138 (RRID:CVCL_B077)
Comments Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Population: Caucasian.
Doubling time: 24 hours (PubMed=25315077).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Miscellaneous: HLA*C loci for PubMed=24362935 was incorrect, modified version submitted by Pellat-Deceunynck, Catherine.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:12032; TRAF2; Simple; p.Trp114Ter (c.341G>A); Zygosity=Unspecified (PubMed=24362935).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,23:01
HLA-BB*08:01,44:05
HLA-CC*02:02,07:06
Class II
HLA-DQDQA1*05:01,01:01
DQB1*05:01,02:01
HLA-DRDRB1*03:01,01:01

Source: PubMed=25688540
Class I
HLA-AA*01,23
HLA-BB*08,44
HLA-CC*02,07
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3001; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819
D3S135816
D5S81811,13
D7S8208
D8S11798,13
D13S3179,12
D16S53911
D18S5114,18
D19S43312,14
D21S1130,32.2
FGA20,22
Penta D13,15
Penta E7,18
TH016
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=9669839; DOI=10.1016/S0145-2126(97)00191-4
Zeev Estrov, Moshe Talpaz, Sherman Ku, David Harris, Quin Van, Miloslav Beran, Cheryl F. Hirsch-Ginsberg, Yang Ok Huh, Garland Yee, Razelle Kurzrock;
Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia.
Leuk. Res. 22:341-353(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016
Catherine A. Tucker, Gwyn Bebb, Richard J. Klasa, Mukesh Chhanabhai, Valia S. Lestou, Douglas E. Horsman, Randy D. Gascoyne, Adrian Wiestner, Dana Masin, Marcel Bally, Michael E. Williams;
Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.
Leuk. Res. 30:449-457(2006)

PubMed=16203034; DOI=10.1016/j.leukres.2005.08.026
L. Jeffrey Medeiros, Zeev Estrov, Georgios Z. Rassidakis;
Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma.
Leuk. Res. 30:497-501(2006)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731
Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A. Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L. Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J. Calasanz ...Show all 18 authors... , Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S. Lossos, Miguel Angel Piris, Martin E. Fernandez-Zapico, Jose Angel Martinez-Climent; Show fewer authors
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=24362935; DOI=10.1038/nm.3435
Rami Rahal, Mareike Frick, Rodrigo Romero, Joshua M. Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Carrie Bhang, David A. Ruddy, Audrey Kauffmann, Ali Farsidjani ...Show all 30 authors... , Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Dorken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John E. Monahan, Michael P. Morrissey, Christine Fritsch, William Raj Sellers, Vesselina G. Cooke, Randy D. Gascoyne, Georg Lenz, Frank Stegmeier; Show fewer authors
Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
Nat. Med. 20:87-92(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25315077; DOI=10.3109/10428194.2014.970548
Laura K. Fogli, Michael E. Williams, Joseph M. Connors, Yvonne A. Reid, Kathleen Brown, Owen A. O'Connor;
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
Leuk. Lymphoma 56:2114-2122(2015)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Sophie Maiga, Carole Brosseau, Geraldine Descamps, Christelle Dousset, Patricia Gomez-Bougie, David Chiron, Emmanuelle Menoret, Charlotte Kervoelen, Henri Vie, Anne Cesbron, Agnes Moreau-Aubry ...Show all 13 authors... , Martine Amiot, Catherine Pellat-Deceunynck; Show fewer authors
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, De-Kuang Zhao, Xiao-Yu Jiang, Elif Isik, Anthony George Letai, Izidore S. Lossos;
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

PubMed=27697772; DOI=10.1182/blood-2016-06-720490
David Chiron, Celine Bellanger, Antonin Papin, Benoit Tessoulin, Christelle Dousset, Sophie Maiga, Anne Moreau, Julie Esbelin, Valerie Trichet, Selina Chen-Kiang, Philippe Moreau ...Show all 15 authors... , Cyrille Touzeau, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunynck; Show fewer authors
Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma.
Blood 128:2808-2818(2016)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

Cross-references
Cell line collections (Providers) ATCC; CRL-3001
Cell line databases/resources cancercelllines; CVCL_B077
Lonza; 1605
Biological sample resources BioSample; SAMN03471023
Chemistry resources ChEMBL-Cells; CHEMBL4483125
ChEMBL-Targets; CHEMBL4483276
PubChem_Cell_line; CVCL_B077
Encyclopedic resources Wikidata; Q54995848
Experimental variables resources EFO; EFO_0005479
Gene expression databases GEO; GSM115807
GEO; GSM629502
GEO; GSM629503
GEO; GSM1044974
GEO; GSM1044975
GEO; GSM1044976
GEO; GSM1044977
GEO; GSM1266779
GEO; GSM1266780
GEO; GSM1266787
GEO; GSM1266788
GEO; GSM1266789
GEO; GSM1266790
GEO; GSM1266791
GEO; GSM1266792
GEO; GSM2322624
Polymorphism and mutation databases Cosmic; 2078183
Cosmic; 2088021
Cosmic; 2296992
Cosmic; 2756238
Progenetix; CVCL_B077
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number31