ID   Z-138
AC   CVCL_B077
SY   Z138
DR   EFO; EFO_0005479
DR   ATCC; CRL-3001
DR   BioSample; SAMN03471023
DR   cancercelllines; CVCL_B077
DR   ChEMBL-Cells; CHEMBL4483125
DR   ChEMBL-Targets; CHEMBL4483276
DR   Cosmic; 2078183
DR   Cosmic; 2088021
DR   Cosmic; 2296992
DR   Cosmic; 2756238
DR   GEO; GSM115807
DR   GEO; GSM629502
DR   GEO; GSM629503
DR   GEO; GSM1044974
DR   GEO; GSM1044975
DR   GEO; GSM1044976
DR   GEO; GSM1044977
DR   GEO; GSM1266779
DR   GEO; GSM1266780
DR   GEO; GSM1266787
DR   GEO; GSM1266788
DR   GEO; GSM1266789
DR   GEO; GSM1266790
DR   GEO; GSM1266791
DR   GEO; GSM1266792
DR   GEO; GSM2322624
DR   Lonza; 1605
DR   Progenetix; CVCL_B077
DR   PubChem_Cell_line; CVCL_B077
DR   Wikidata; Q54995848
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9669839;
RX   PubMed=16183118;
RX   PubMed=16203034;
RX   PubMed=16960149;
RX   PubMed=21746927;
RX   PubMed=24362935;
RX   PubMed=25315077;
RX   PubMed=25688540;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26194763;
RX   PubMed=27697772;
RX   PubMed=29666304;
CC   Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
CC   Population: Caucasian.
CC   Doubling time: 24 hours (PubMed=25315077).
CC   HLA typing: A*01:01,23:01; B*08:01,44:05; C*02:02,07:06; DQA1*05:01,01:01; DQB1*05:01,02:01; DRB1*03:01,01:01 (PubMed=25960936).
CC   HLA typing: A*01,23; B*08,44; C*02,07 (PubMed=25688540).
CC   Sequence variation: Mutation; HGNC; HGNC:12032; TRAF2; Simple; p.Trp114Ter (c.341G>A); Zygosity=Unspecified (PubMed=24362935).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Miscellaneous: HLA*C loci for PubMed=24362935 was incorrect, modified version submitted by Pellat-Deceunynck, Catherine.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-3001; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 11
ST   D18S51: 14,18
ST   D19S433: 12,14
ST   D21S11: 30,32.2
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 11,13
ST   D7S820: 8
ST   D8S1179: 8,13
ST   FGA: 20,22
ST   Penta D: 13,15
ST   Penta E: 7,18
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C4337; Mantle cell lymphoma
DI   ORDO; Orphanet_52416; Mantle cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela, Cinta
RA   Rubio-Moscardo, Fanny
RA   Richter, Jose A.
RA   Siebert, Reiner
RA   Climent, Joan
RA   Fresquet, Vicente
RA   Beltran, Elena
RA   Agirre, Xabier
RA   Marugan, Isabel
RA   Marin, Miguel
RA   Rosenwald, Andreas
RA   Sugimoto, Kei-ji
RA   Wheat, Luise M.
RA   Karran, E. Loraine
RA   Garcia Garcia, Juan Fernando
RA   Sanchez-Verde, Lydia
RA   Prosper, Felipe
RA   Staudt, Louis Michael
RA   Pinkel, Daniel
RA   Dyer, Martin John Swinnerton
RA   Martinez-Climent, Jose Angel
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731;
RA   Beltran, Elena
RA   Fresquet, Vicente
RA   Martinez-Useros, Javier
RA   Richter-Larrea, Jose A.
RA   Sagardoy, Ainara
RA   Sesma, Izaskun
RA   Almada, Luciana L.
RA   Montes-Moreno, Santiago
RA   Siebert, Reiner
RA   Gesk, Stefan
RA   Calasanz, Maria J.
RA   Malumbres, Raquel
RA   Rieger, Melissa
RA   Prosper, Felipe
RA   Lossos, Izidore S.
RA   Piris, Miguel Angel
RA   Fernandez-Zapico, Martin E.
RA   Martinez-Climent, Jose Angel
RT   "A cyclin-D1 interaction with BAX underlies its oncogenic role and
RT   potential as a therapeutic target in mantle cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).
//
RX   PubMed=25315077; DOI=10.3109/10428194.2014.970548;
RA   Fogli, Laura K.
RA   Williams, Michael E.
RA   Connors, Joseph M.
RA   Reid, Yvonne A.
RA   Brown, Kathleen
RA   O'Connor, Owen A.
RT   "Development and characterization of a Mantle Cell Lymphoma Cell Bank
RT   in the American Type Culture Collection.";
RL   Leuk. Lymphoma 56:2114-2122(2015).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332;
RA   Bhatt, Shruti
RA   Matthews, Julie
RA   Parvin, Salma
RA   Sarosiek, Kristopher A.
RA   Zhao, De-Kuang
RA   Jiang, Xiao-Yu
RA   Isik, Elif
RA   Letai, Anthony George
RA   Lossos, Izidore S.
RT   "Direct and immune-mediated cytotoxicity of interleukin-21 contributes
RT   to antitumor effects in mantle cell lymphoma.";
RL   Blood 126:1555-1564(2015).
//
RX   PubMed=27697772; DOI=10.1182/blood-2016-06-720490;
RA   Chiron, David
RA   Bellanger, Celine
RA   Papin, Antonin
RA   Tessoulin, Benoit
RA   Dousset, Christelle
RA   Maiga, Sophie
RA   Moreau, Anne
RA   Esbelin, Julie
RA   Trichet, Valerie
RA   Chen-Kiang, Selina
RA   Moreau, Philippe
RA   Touzeau, Cyrille
RA   Le Gouill, Steven
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "Rational targeted therapies to overcome microenvironment-dependent
RT   expansion of mantle cell lymphoma.";
RL   Blood 128:2808-2818(2016).
//
RX   PubMed=16203034; DOI=10.1016/j.leukres.2005.08.026;
RA   Medeiros, L. Jeffrey
RA   Estrov, Zeev
RA   Rassidakis, Georgios Z.
RT   "Z-138 cell line was derived from a patient with blastoid variant
RT   mantle cell lymphoma.";
RL   Leuk. Res. 30:497-501(2006).
//
RX   PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004;
RA   Pham, Lan V.
RA   Huang, Sheng-Jian
RA   Zhang, Hui
RA   Zhang, Jun
RA   Bell, Taylor
RA   Zhou, Shou-Hao
RA   Pogue, Elizabeth
RA   Ding, Zhi-Yong
RA   Lam, Laura
RA   Westin, Jason
RA   Davis, R. Eric
RA   Young, Ken H.
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Nomie, Krystle
RA   Zhang, Leo
RA   Wang, Michael
RT   "Strategic therapeutic targeting to overcome venetoclax resistance in
RT   aggressive B-cell lymphomas.";
RL   Clin. Cancer Res. 24:3967-3980(2018).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=25688540; DOI=10.1002/cyto.a.22643;
RA   Maiga, Sophie
RA   Brosseau, Carole
RA   Descamps, Geraldine
RA   Dousset, Christelle
RA   Gomez-Bougie, Patricia
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Kervoelen, Charlotte
RA   Vie, Henri
RA   Cesbron, Anne
RA   Moreau-Aubry, Agnes
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A simple flow cytometry-based barcode for routine authentication of
RT   multiple myeloma and mantle cell lymphoma cell lines.";
RL   Cytometry A 87:285-288(2015).
//
RX   PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016;
RA   Tucker, Catherine A.
RA   Bebb, Gwyn
RA   Klasa, Richard J.
RA   Chhanabhai, Mukesh
RA   Lestou, Valia S.
RA   Horsman, Douglas E.
RA   Gascoyne, Randy D.
RA   Wiestner, Adrian
RA   Masin, Dana
RA   Bally, Marcel
RA   Williams, Michael E.
RT   "Four human t(11;14)(q13;q32)-containing cell lines having classic and
RT   variant features of mantle cell lymphoma.";
RL   Leuk. Res. 30:449-457(2006).
//
RX   PubMed=24362935; DOI=10.1038/nm.3435;
RA   Rahal, Rami
RA   Frick, Mareike
RA   Romero, Rodrigo
RA   Korn, Joshua M.
RA   Kridel, Robert
RA   Chan, Fong Chun
RA   Meissner, Barbara
RA   Bhang, Hyo-eun Carrie
RA   Ruddy, David A.
RA   Kauffmann, Audrey
RA   Farsidjani, Ali
RA   Derti, Adnan
RA   Rakiec, Daniel
RA   Naylor, Tara
RA   Pfister, Estelle
RA   Kovats, Steve
RA   Kim, Sunkyu
RA   Dietze, Kerstin
RA   Dorken, Bernd
RA   Steidl, Christian
RA   Tzankov, Alexandar
RA   Hummel, Michael
RA   Monahan, John E.
RA   Morrissey, Michael P.
RA   Fritsch, Christine
RA   Sellers, William Raj
RA   Cooke, Vesselina G.
RA   Gascoyne, Randy D.
RA   Lenz, Georg
RA   Stegmeier, Frank
RT   "Pharmacological and genomic profiling identifies NF-kappaB-targeted
RT   treatment strategies for mantle cell lymphoma.";
RL   Nat. Med. 20:87-92(2014).
//
RX   PubMed=9669839; DOI=10.1016/S0145-2126(97)00191-4;
RA   Estrov, Zeev
RA   Talpaz, Moshe
RA   Ku, Sherman
RA   Harris, David M.
RA   Van, Quin
RA   Beran, Miloslav
RA   Hirsch-Ginsberg, Cheryl F.
RA   Huh, Yang Ok
RA   Yee, Garland
RA   Kurzrock, Razelle
RT   "Z-138: a new mature B-cell acute lymphoblastic leukemia cell line
RT   from a patient with transformed chronic lymphocytic leukemia.";
RL   Leuk. Res. 22:341-353(1998).
//