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Cellosaurus MeWo CIS 0.01 (CVCL_AZ60)

[Text version]
Cell line name MeWo CIS 0.01
Synonyms MeWo-cisplatin 0.01
Accession CVCL_AZ60
Resource Identification Initiative To cite this cell line use: MeWo CIS 0.01 (RRID:CVCL_AZ60)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Proteomics; 2DE.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0445 (MeWo)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
Publications

PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W
Pranav Sinha, Sandra Kohl, Jochen Fischer, Gero Hutter, Monika Kern, Eckart Kottgen, Manfred Dietel, Hermann Lage, Martina Schnolzer, Dirk Schadendorf;
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Electrophoresis 21:3048-3057(2000)

PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V
Claudia Grottke, Klaus Mantwill, Manfred Dietel, Dirk Schadendorf, Hermann Lage;
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
Int. J. Cancer 88:535-546(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AZ60
Encyclopedic resources Wikidata; Q54905337
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number15