ID   MeWo CIS 0.01
AC   CVCL_AZ60
SY   MeWo-cisplatin 0.01
DR   cancercelllines; CVCL_AZ60
DR   Wikidata; Q54905337
RX   PubMed=11001322;
RX   PubMed=11058868;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
CC   Omics: Proteome analysis by 2D-DE.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0445 ! MeWo
SX   Male
AG   78Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 30-01-24; Version: 12
//
RX   PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W;
RA   Sinha P., Kohl S., Fischer J., Hutter G., Kern M., Kottgen E.,
RA   Dietel M., Lage H., Schnolzer M., Schadendorf D.;
RT   "Identification of novel proteins associated with the development of
RT   chemoresistance in malignant melanoma using two-dimensional
RT   electrophoresis.";
RL   Electrophoresis 21:3048-3057(2000).
//
RX   PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V;
RA   Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.;
RT   "Identification of differentially expressed genes in human melanoma
RT   cells with acquired resistance to various antineoplastic drugs.";
RL   Int. J. Cancer 88:535-546(2000).
//