ID   MeWo CIS 0.01
AC   CVCL_AZ60
SY   MeWo-cisplatin 0.01
DR   cancercelllines; CVCL_AZ60
DR   Wikidata; Q54905337
RX   PubMed=11001322;
RX   PubMed=11058868;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
CC   Omics: Proteomics; 2DE.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0445 ! MeWo
SX   Male
AG   78Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 10-04-25; Version: 15
//
RX   PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W;
RA   Sinha, Pranav
RA   Kohl, Sandra
RA   Fischer, Jochen
RA   Hutter, Gero
RA   Kern, Monika
RA   Kottgen, Eckart
RA   Dietel, Manfred
RA   Lage, Hermann
RA   Schnolzer, Martina
RA   Schadendorf, Dirk
RT   "Identification of novel proteins associated with the development of
RT   chemoresistance in malignant melanoma using two-dimensional
RT   electrophoresis.";
RL   Electrophoresis 21:3048-3057(2000).
//
RX   PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V;
RA   Grottke, Claudia
RA   Mantwill, Klaus
RA   Dietel, Manfred
RA   Schadendorf, Dirk
RA   Lage, Hermann
RT   "Identification of differentially expressed genes in human melanoma
RT   cells with acquired resistance to various antineoplastic drugs.";
RL   Int. J. Cancer 88:535-546(2000).
//