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Cellosaurus SDAR2 (CVCL_AV64)

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Cell line name SDAR2
Accession CVCL_AV64
Resource Identification Initiative To cite this cell line use: SDAR2 (RRID:CVCL_AV64)
Comments Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Val54fs (c.160delG); Zygosity=Homozygous (PubMed=29846633; PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (PubMed=29846633; PubMed=30737244).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val217fs (c.648delG); Zygosity=Homozygous (PubMed=29846633; PubMed=30737244).
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_AV63 ! SDAR1
CVCL_AV65 ! SDAR3
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=29846633; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11
D3S135817
D5S81813
D7S8209,10
D8S117914
D13S3178 (PubMed=29846633)
8,12 (PubMed=30737244)
D16S53911
D18S5116
D21S1130
FGA27
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

CLPUB00321
Laura A. Marlow, Stephen Davis Rohl, Gregory T. Kennedy, Dragana Milosevic, Stefan K.G. Grebe, Honey V. Reddi, Norman L. Eberhardt, John C. Morris, Maria A. Trujillo, Samantha J. McDonough, Bryan McIver ...Show all 15 authors... , Keith C. Bible, John D. Casler, Robert Christian Smallridge, John Alton Copland 3rd; Show fewer authors
Newly characterized follicular thyroid carcinoma cell lines demonstrate antitumor synergy in response to combined MEK and AKT inhibitors.
(In conference) 82nd annual meeting of the American Thyroid Association; pp.A61-A61; American Thyroid Association; Quebec; Canada (2012)

PubMed=29846633; DOI=10.1210/jc.2017-01845; PMCID=PMC6126888
Laura A. Marlow, Stephen Davis Rohl, James L. Miller, Jeffrey A. Knauf, James Alexander Fagin, Mabel M. Ryder, Dragana Milosevic, Brian C. Netzel, Stefan K.G. Grebe, Honey V. Reddi, Robert Christian Smallridge, John Alton Copland 3rd;
Methodology, criteria, and characterization of patient-matched thyroid cell lines and patient-derived tumor xenografts.
J. Clin. Endocrinol. Metab. 103:3169-3182(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) ABM; T8258
Encyclopedic resources Wikidata; Q54952712
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number14