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Cellosaurus COG-N-291 (CVCL_AQ18)

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Cell line name COG-N-291
Accession CVCL_AQ18
Resource Identification Initiative To cite this cell line use: COG-N-291 (RRID:CVCL_AQ18)
Comments Characteristics: Has long and heterogeneous telomeres and no telomerase activity. Its telomeres shortens continuously at an average rate of 80 base pairs per population doubling (PubMed=28636942).
Doubling time: 3.4 days (PubMed=28636942); 224 hours (COG).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Children
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX
CSF1PO11,13
D2S133819,23
D3S135816
D5S81811
D7S82011,12
D8S117912,14
D13S31712,13
D16S53911,12
D18S5112,15
D19S43313,14
D21S1129
FGA21,22
TH019
TPOX8,11
vWA16,17

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Publications

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=28636942; DOI=10.1016/j.celrep.2017.05.087
Rebecca A. Dagg, Hilda A. Pickett, Axel A. Neumann, Christine E. Napier, Jeremy David Henson, Erdahl T. Teber, Jonathan W. Arthur, Charles Patrick Reynolds, Jayne Murray, Michelle Haber, Alexander Peter Sobinoff ...Show all 13 authors... , Loretta M.S. Lau, Roger Robert Reddel; Show fewer authors
Extensive proliferation of human cancer cells with ever-shorter telomeres.
Cell Rep. 19:2544-2556(2017)

Cross-references
Encyclopedic resources Wikidata; Q54813985
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number7