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Cellosaurus LAMA84R (CVCL_AE17)

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Cell line name LAMA84R
Synonyms LAMA84-R
Accession CVCL_AE17
Resource Identification Initiative To cite this cell line use: LAMA84R (RRID:CVCL_AE17)
Comments Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0388 (LAMA-84)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
Publications

PubMed=10688835; DOI=10.1182/blood.V95.5.1758.005a41_1758_1766
Philipp le Coutre, Elena Tassi, Marileila Varella-Garcia, Rossella Barni, Luca Mologni, Goncalo Cabrita, Edoardo Marchesi, Rosanna Supino, Carlo Gambacorti-Passerini;
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification.
Blood 95:1758-1766(2000)

Cross-references
Encyclopedic resources Wikidata; Q54901919
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number13