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Cellosaurus NYSCF-AD-1019-AG07889-Skin-RV-IPSC1 (CVCL_AD15)

[Text version]
Cell line name NYSCF-AD-1019-AG07889-Skin-RV-IPSC1
Synonyms 7889SA
Accession CVCL_AD15
Resource Identification Initiative To cite this cell line use: NYSCF-AD-1019-AG07889-Skin-RV-IPSC1 (RRID:CVCL_AD15)
Comments From: New York Stem Cell Foundation; New York; USA.
Population: Caucasian; Italian.
Donor information: At sampling donor was not affected with Alzheimer disease but has a 25% risk (from parent cell line).
Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Alzheimer's disease 3 (NCIt: C123412)
Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4K02 (AG07889)
Children:
CVCL_E7G7 (7889SA APP(Swe/Swe))CVCL_E7G8 (7889SA APP(WT/Swe))CVCL_E7G9 (7889SA PSEN1(M146V/M146V))
CVCL_E7GA (7889SA PSEN1(WT/M146V))CVCL_E7GB (7889SA-iCas9)
Sex of cell Male
Age at sampling 17Y8M
Category Induced pluripotent stem cell
Publications

PubMed=24416243; DOI=10.1371/journal.pone.0084547; PMCID=PMC3885572
Sproul A.A., Jacob S., Pre D., Kim S.H., Nestor M.W., Navarro-Sobrino M., Santa-Maria I., Zimmer M., Aubry S., Steele J.W., Kahler D.J., Dranovsky A., Arancio O., Crary J.F., Gandy S.E., Noggle S.A.
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.
PLoS ONE 9:e84547.1-e84547.11(2014)

PubMed=27120160; DOI=10.1038/nature17664
Paquet D., Kwart D.G., Chen A., Sproul A.A., Jacob S., Teo S., Olsen K.M., Gregg A., Noggle S.A., Tessier-Lavigne M.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature 533:125-129(2016)

Cross-references
Cell line databases/resources SKIP; SKIP004869
Encyclopedic resources Wikidata; Q54931387
Entry history
Entry creation23-Feb-2016
Last entry update10-Apr-2025
Version number12