ID   NYSCF-AD-1019-AG07889-Skin-RV-IPSC1
AC   CVCL_AD15
SY   7889SA
DR   SKIP; SKIP004869
DR   Wikidata; Q54931387
RX   PubMed=24416243;
RX   PubMed=27120160;
CC   From: New York Stem Cell Foundation; New York; USA.
CC   Population: Caucasian; Italian.
CC   Donor information: At sampling donor was not affected with Alzheimer disease but has a 25% risk (from parent cell line).
CC   Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C123412; Alzheimer's disease 3
DI   ORDO; Orphanet_1020; Early-onset autosomal dominant Alzheimer disease
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4K02 ! AG07889
SX   Male
AG   17Y8M
CA   Induced pluripotent stem cell
DT   Created: 23-02-16; Last updated: 10-04-25; Version: 12
//
RX   PubMed=24416243; DOI=10.1371/journal.pone.0084547; PMCID=PMC3885572;
RA   Sproul A.A., Jacob S., Pre D., Kim S.H., Nestor M.W.,
RA   Navarro-Sobrino M., Santa-Maria I., Zimmer M., Aubry S., Steele J.W.,
RA   Kahler D.J., Dranovsky A., Arancio O., Crary J.F., Gandy S.E.,
RA   Noggle S.A.;
RT   "Characterization and molecular profiling of PSEN1 familial
RT   Alzheimer's disease iPSC-derived neural progenitors.";
RL   PLoS ONE 9:e84547.1-e84547.11(2014).
//
RX   PubMed=27120160; DOI=10.1038/nature17664;
RA   Paquet D., Kwart D.G., Chen A., Sproul A.A., Jacob S., Teo S.,
RA   Olsen K.M., Gregg A., Noggle S.A., Tessier-Lavigne M.;
RT   "Efficient introduction of specific homozygous and heterozygous
RT   mutations using CRISPR/Cas9.";
RL   Nature 533:125-129(2016).
//