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Cellosaurus CTSC#446 (CVCL_A9WW)

[Text version]
Cell line name CTSC#446
Synonyms CRC-SC#446
Accession CVCL_A9WW
Resource Identification Initiative To cite this cell line use: CTSC#446 (RRID:CVCL_A9WW)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; 172; ACVR1B; Simple; p.Met361Leu (c.1081A>C); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 172; ACVR1B; Simple; p.Glu482Gly (c.1445A>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Asp412Gly (c.1235A>G); ClinVar=VCV001498964; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Arg717His (c.2150G>A); dbSNP=rs753246841; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Ser142Arg (c.424A>C); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Ser678Ter (c.2033C>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Asp105Val (c.314A>T); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Cys186Tyr (c.557G>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 9588; PTEN; Simple; p.His93Arg (c.278A>G); ClinVar=VCV000007848; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu182Ser (c.545T>C); ClinVar=VCV000187827; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6768; SMAD2; Simple; p.Asn34Asp (c.100A>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6768; SMAD2; Simple; p.Leu254Phe (c.760C>T); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11204; SOX9; Simple; p.Pro108His (c.323C>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11641; TCF7L2; Simple; p.Gln263Arg (c.788A>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala189Profs*58 (c.565delG); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11998; TP53; Simple; p.Phe270Cys (c.809T>G); ClinVar=VCV000376597; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 87Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX
CSF1PO11
D5S81813
D7S82010,11
D13S3179,12
D16S53911,13
TH019.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WW
Encyclopedic resources Wikidata; Q102113753
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number8