ID   CTSC#446
AC   CVCL_A9WW
SY   CRC-SC#446
DR   cancercelllines; CVCL_A9WW
DR   Wikidata; Q102113753
RX   PubMed=33128777;
CC   Group: Cancer stem cell line.
CC   From: Sant Andrea Hospital; Rome; Italy.
CC   Microsatellite instability: Stable (MSS) (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:172; ACVR1B; Simple; p.Met361Leu (c.1081A>C); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:172; ACVR1B; Simple; p.Glu482Gly (c.1445A>G); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Asp412Gly (c.1235A>G); ClinVar=VCV001498964; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Arg717His (c.2150G>A); ClinVar=VCV001208710; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Ser142Arg (c.424A>C); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Ser678Ter (c.2033C>G); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Asp105Val (c.314A>T); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Cys186Tyr (c.557G>A); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.His93Arg (c.278A>G); ClinVar=VCV000007848; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu182Ser (c.545T>C); ClinVar=VCV000187827; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Asn34Asp (c.100A>G); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Leu254Phe (c.760C>T); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:11204; SOX9; Simple; p.Pro108His (c.323C>A); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:11641; TCF7L2; Simple; p.Gln263Arg (c.788A>G); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala189Profs*58 (c.565delG); ClinVar=VCV003148285; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Phe270Cys (c.809T>G); ClinVar=VCV000376597; Zygosity=Unspecified (PubMed=33128777).
CC   Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
ST   Source(s): PubMed=33128777
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9,12
ST   D16S539: 11,13
ST   D5S818: 13
ST   D7S820: 10,11
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   87Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 27-11-25; Version: 10
//
RX   PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552;
RA   Visconti, Paola
RA   Parodi, Federica
RA   Parodi, Barbara
RA   Casarino, Lucia
RA   Romano, Paolo
RA   Buccarelli, Mariachiara
RA   Pallini, Roberto
RA   D'Alessandris, Quintino Giorgio
RA   Montori, Andrea
RA   Pilozzi, Emanuela
RA   Ricci-Vitiani, Lucia
RT   "Short tandem repeat profiling for the authentication of cancer
RT   stem-like cells.";
RL   Int. J. Cancer 148:1489-1498(2021).
//