Cell line name |
CTSC#1.2 |
Synonyms |
CRC-SC#1.2 |
Accession |
CVCL_A9WI |
Resource Identification Initiative |
To cite this cell line use: CTSC#1.2 (RRID:CVCL_A9WI) |
Comments |
Group: Cancer stem cell line. From: Sant Andrea Hospital; Rome; Italy. Microsatellite instability: Stable (MSS) (PubMed=33128777). Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971. |
Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Thr182Ilefs*2 (c.543_546delACAA); ClinVar=VCV000470005; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 583; APC; Simple; p.Arg259Trp (c.775C>T); ClinVar=VCV000411556; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 583; APC; Simple; p.Glu1284Ter (c.3850G>T); ClinVar=VCV000946474; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Pro606Ala (c.1816C>G); Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Arg361Cys (c.1081C>T); ClinVar=VCV000008543; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 11641; TCF7L2; Simple; p.Leu200Profs*10 (c.593_594insC); Zygosity=Unspecified (PubMed=33128777).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Originate from same individual |
CVCL_A9WH ! CTSC#1.1 |
Sex of cell |
Male |
Age at sampling |
68Y |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=33128777
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083 Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L. UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response. Oncotarget 7:44113-44128(2016) PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552 Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L. Short tandem repeat profiling for the authentication of cancer stem-like cells. Int. J. Cancer 148:1489-1498(2021) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_A9WI
|
Encyclopedic resources |
Wikidata; Q102113737
|
Entry history |
Entry creation | 29-Oct-2020 |
Last entry update | 05-Oct-2023 |
Version number | 7 |
---|