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Cellosaurus CTSC#1.2 (CVCL_A9WI)

[Text version]
Cell line name CTSC#1.2
Synonyms CRC-SC#1.2
Accession CVCL_A9WI
Resource Identification Initiative To cite this cell line use: CTSC#1.2 (RRID:CVCL_A9WI)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr182Ilefs*2 (c.543_546delACAA); ClinVar=VCV000470005; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Arg259Trp (c.775C>T); ClinVar=VCV000411556; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Glu1284Ter (c.3850G>T); ClinVar=VCV000946474; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Pro606Ala (c.1816C>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg361Cys (c.1081C>T); ClinVar=VCV000008543; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11641; TCF7L2; Simple; p.Leu200Profs*10 (c.593_594insC); Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A9WH ! CTSC#1.1
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811,13
D7S82010
D13S3178,9
D16S5399,11
TH018,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WI
Encyclopedic resources Wikidata; Q102113737
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7