ID   CTSC#1.2
AC   CVCL_A9WI
SY   CRC-SC#1.2
DR   cancercelllines; CVCL_A9WI
DR   Wikidata; Q102113737
RX   PubMed=27286453;
RX   PubMed=33128777;
CC   Group: Cancer stem cell line.
CC   From: Sant Andrea Hospital; Rome; Italy.
CC   Microsatellite instability: Stable (MSS) (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr182Ilefs*2 (c.543_546delACAA); ClinVar=VCV000470005; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg259Trp (c.775C>T); ClinVar=VCV000411556; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1284Ter (c.3850G>T); ClinVar=VCV000946474; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Pro606Ala (c.1816C>G); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Arg361Cys (c.1081C>T); ClinVar=VCV000008543; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; HGNC:11641; TCF7L2; Simple; p.Leu200Profs*10 (c.593_594insC); Zygosity=Unspecified (PubMed=33128777).
CC   Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971.
ST   Source(s): PubMed=33128777
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,9
ST   D16S539: 9,11
ST   D5S818: 11,13
ST   D7S820: 10
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A9WH ! CTSC#1.1
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 19-12-24; Version: 8
//
RX   PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083;
RA   Signore, Michele
RA   Buccarelli, Mariachiara
RA   Pilozzi, Emanuela
RA   De Luca, Gabriele
RA   Cappellari, Marianna
RA   Fanciulli, Maurizio
RA   Goeman, Frauke
RA   Melucci, Elisa
RA   Biffoni, Mauro
RA   Ricci-Vitiani, Lucia
RT   "UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer
RT   stem-like cells by impairing DNA damage response.";
RL   Oncotarget 7:44113-44128(2016).
//
RX   PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552;
RA   Visconti, Paola
RA   Parodi, Federica
RA   Parodi, Barbara
RA   Casarino, Lucia
RA   Romano, Paolo
RA   Buccarelli, Mariachiara
RA   Pallini, Roberto
RA   D'Alessandris, Quintino Giorgio
RA   Montori, Andrea
RA   Pilozzi, Emanuela
RA   Ricci-Vitiani, Lucia
RT   "Short tandem repeat profiling for the authentication of cancer
RT   stem-like cells.";
RL   Int. J. Cancer 148:1489-1498(2021).
//