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Cellosaurus GIST430B (CVCL_A9N1)

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Cell line name GIST430B
Accession CVCL_A9N1
Resource Identification Initiative To cite this cell line use: GIST430B (RRID:CVCL_A9N1)
Comments Characteristics: Has lost KIT protein expression (PubMed=30488756).
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Omics: Genomics; ChIP-seq; H3K27ac.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Leu576del (c.1678_1728del); ClinVar=VCV000523644; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val654Ala (c.1961T>C); ClinVar=VCV000375921; Zygosity=Heterozygous (from parent cell line).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7040 (GIST430)
Category Cancer cell line
Publications

PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782
Matthew L. Hemming, Matthew A. Lawlor, Rhamy Zeid, Tom Lesluyes, Jonathan A. Fletcher, Chandrajit P. Raut, Ewa T. Sicinska, Frederic Chibon, Scott Allen Armstrong, George Daniel Demetri, James E. Bradner;
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111
Yu-Qing Tu, Rui Zuo, Nan Ni, Grant Eilers, Duo-Lin Wu, Yu-Ting Pei, Zuo-Ming Nie, Ye-Qing Wu, Yue-Hong Wu, Wen-Bin Ou;
Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression.
Cell Cycle 17:2577-2592(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9N1
Encyclopedic resources Wikidata; Q102113883
Gene expression databases GEO; GSM2527266
GEO; GSM2527267
Entry history
Entry creation29-Oct-2020
Last entry update10-Apr-2025
Version number8