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Cellosaurus S1-IR20 (CVCL_A9DE)

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Cell line name S1-IR20
Accession CVCL_A9DE
Resource Identification Initiative To cite this cell line use: S1-IR20 (RRID:CVCL_A9DE)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0H88 (S1)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=33692943; DOI=10.3389/fonc.2020.624954; PMCID=PMC7937870
Zhuo-Xun Wu, Yu-Qi Yang, Le-Li Zeng, Harsh Patel, Le-Tao Bo, Lu-Sheng Lin, Zhe-Sheng Chen;
Establishment and characterization of an irinotecan-resistant human colon cancer cell line.
Front. Oncol. 10:624954.1-624954.8(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9DE
Encyclopedic resources Wikidata; Q108821254
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6