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Cellosaurus Ecad-231-7 (CVCL_A9BP)

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Cell line name Ecad-231-7
Synonyms Ecad231-7
Accession CVCL_A9BP
Resource Identification Initiative To cite this cell line use: Ecad-231-7 (RRID:CVCL_A9BP)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1748; CDH1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=21215101; DOI=10.3760/cma.j.issn.0529-5807.2010.12.011
Li-Juan Yang, Yu-Qin Liu, Bei Gu, Xiao-Cui Bian, Hai-Liang Feng, Zhen-Li Yang, Yan-Yan Liu;
Effect of forced E-cadherin expression on adhesion and proliferation of human breast carcinoma cells.
Zhonghua Bing Li Xue Za Zhi 39:842-847(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9BP
CCRID; 1101HUM-PUMC000398
Encyclopedic resources Wikidata; Q108820180
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number9